Open AccessEffects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system
Author(s) -
Julia J. Segura-Uribe,
Rodolfo PintoAlmazán,
Angélica Coyoy-Salgado,
Claudia Erika FuentesVenado,
Christian GuerraAraiza
Publication year - 2017
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.213536
Subject(s) - estrogen receptor , neuroprotection , cytoskeleton , estrogen , selective estrogen receptor modulator , raloxifene , tamoxifen , receptor , medicine , neuroscience , endocrinology , pharmacology , chemistry , biology , breast cancer , cancer , biochemistry , cell
Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1 (MAP1), MAP2, neurofilament 38 (NF38) by different mechanisms of action and at different levels: neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects.