Open AccessMagnetic resonance diffusion tensor imaging following major ozonated autohemotherapy for treatment of acute cerebral infarction
Author(s) -
Xiaona Wu,
Tao Zhang,
Jun Wang,
Xiaoyan Liu,
Zhensheng Li,
Wei Xiang,
Wei Du,
Hongjun Yang,
Tie-gen Xiong,
Wenting Deng,
Kairun Peng,
Suyue Pan
Publication year - 2016
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.187046
Subject(s) - medicine , fractional anisotropy , modified rankin scale , cerebral infarction , magnetic resonance imaging , diffusion mri , anesthesia , infarction , stroke (engine) , surgery , ischemia , ischemic stroke , myocardial infarction , radiology , mechanical engineering , engineering
Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether major ozonated autohemotherapy affects remote injury remains poorly understood. Here, we assumed that major ozonated autohemotherapy contributes to recovery of clinical function, possibly by reducing remote injury after acute cerebral infarction. Sixty acute cerebral infarction patients aged 30-80 years were equally and randomly allocated to ozone treatment and control groups. Patients in the ozone treatment group received medical treatment and major ozonated autohemotherapy (47 mg/L, 100 mL ozone) for 10 ± 2 days. Patients in the control group received medical treatment only. National Institutes of Health Stroke Scale score, modified Rankin scale score, and reduced degree of fractional anisotropy values of brain magnetic resonance diffusion tensor imaging were remarkably decreased, brain function improved, clinical efficiency significantly increased, and no obvious adverse reactions detected in the ozone treatment group compared with the control group. These findings suggest that major ozonated autohemotherapy promotes recovery of neurological function in acute cerebral infarction patients by reducing remote injury, and additionally, exhibits high safety.