Open AccessEndogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia
Author(s) -
Xu-Yang Wang,
Peng Gu,
Shiwen Chen,
Wenwei Gao,
Tian Huang,
Xianghe Lu,
Wenjie Zheng,
Qichuan Zhuge,
Weixing Hu
Publication year - 2015
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.170318
Subject(s) - sprouting , neuroscience , neurotrophin 3 , endogeny , dorsum , neurotrophin , dorsal root ganglion , biology , anatomy , medicine , neurotrophic factors , receptor , brain derived neurotrophic factor , endocrinology , botany
In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy. The left L1-5 and L7-S2 dorsal root ganglia in adult cats were exposed and removed, preserving the L6 dorsal root ganglia. Neurotrophin-3 was mainly expressed in large neurons in the dorsal root ganglia and in some neurons in spinal lamina II. Two months after rhizotomy, the number of neurotrophin-3-positive neurons in the spared dorsal root ganglia and the density of neurite sprouts emerging from these ganglia were increased. Intraperitoneal injection of an antibody against neurotrophin-3 decreased the density of neurite sprouts. These findings suggest that endogenous neurotrophin-3 is involved in spinal cord plasticity and regeneration, and that it promotes axonal sprouting from the dorsal root ganglia after spinal cord dorsal root rhizotomy.