Open AccessThe treatment of Parkinson′s disease with deep brain stimulation: current issues
Author(s) -
AlexiaSabine Moldovan,
Stefan Jun Groiss,
Saskia Elben,
Martin Südmeyer,
Alfons Schnitzler,
Lars Wojtecki
Publication year - 2015
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.160094
Subject(s) - deep brain stimulation , medicine , brain stimulation , stimulation , disease , physical medicine and rehabilitation , parkinson's disease , neuropsychology , motor symptoms , neuroscience , quality of life (healthcare) , physical therapy , psychology , psychiatry , cognition , nursing
Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients' mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation.