Open AccessPhage display: development of nanocarriers for targeted drug delivery to the brain
Author(s) -
Babak Bakhshinejad,
Marzieh Karimi,
Mohammad KhalajKondori
Publication year - 2015
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.158330
Subject(s) - nanocarriers , drug delivery , phage display , blood–brain barrier , nanobiotechnology , targeted drug delivery , homing (biology) , drug , biomimetic materials , medicine , nanotechnology , computational biology , pharmacology , peptide , chemistry , biology , central nervous system , nanoparticle , materials science , biochemistry , ecology
The blood brain barrier represents a formidable obstacle for the transport of most systematically administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strategy that can be used for the construction of nanomaterial peptide libraries. These libraries can be screened for finding brain targeting peptide ligands. Surface functionalization of a variety of nanocarriers with these brain homing peptides is a sophisticated way to develop nanobiotechnology-based drug delivery platforms that are able to cross the blood brain barrier. These efficient drug delivery systems raise our hopes for the diagnosis and treatment of various brain disorders in the future.