Open AccessNeuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study
Author(s) -
Alexandria M. Reynolds,
Denise M. Peters,
Jennifer M. C. Vendemia,
Lenwood P Smith,
Raymond C Sweet,
Gordon C. Baylis,
Debra E. Krotish,
Stacy L. Fritz
Publication year - 2014
Publication title -
neural regeneration research/neural regeneration research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.93
H-Index - 38
eISSN - 1876-7958
pISSN - 1673-5374
DOI - 10.4103/1673-5374.131589
Subject(s) - lesion , motor cortex , medicine , voxel , stroke (engine) , corona radiata (embryology) , neuroscience , putamen , physical medicine and rehabilitation , caudate nucleus , cerebral cortex , cortex (anatomy) , psychology , pathology , radiology , mechanical engineering , cumulus oophorus , stimulation , ovarian follicle , hormone , engineering
Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.