Open AccessAbsence of p53 gene expression in selenium molecular prevention of chemically Induced hepatocarcinogenesis in rats
Author(s) -
Nasar Alwahaibi,
Siti Balkis Budin,
Jamaludin Mohamed
Publication year - 2011
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.84489
Subject(s) - selenium , medicine , therapeutic effect , gene expression , cancer research , gene , lymphoma , pharmacology , biology , chemistry , genetics , organic chemistry
p53 pathway is thought by many researchers to be critically involved in selenium's chemoprevention or in hepatocarcinogenesis. The aim of this study was to investigate the gene expression of p53, p21 and B-cell lymphoma-2 (bcl-2) using preventive and therapeutic approaches of selenium in chemically induced hepatocarcinogenesis in rats.