Open AccessGenetic polymorphisms in non-alcoholic fatty liver disease in obese Egyptian children
Author(s) -
Nehal El-Koofy,
Hanaa ElKaraksy,
Iman M Mandour,
Ghada M. Anwar,
Mona El-Raziky,
Ahmad El-Hennawy
Publication year - 2011
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.82582
Subject(s) - medicine , steatohepatitis , genotype , fatty liver , triglyceride , gastroenterology , liver biopsy , overweight , endocrinology , steatosis , obesity , biopsy , biology , disease , gene , genetics , cholesterol
Polymorphisms in the promoter of microsomal triglyceride transfer protein (MTP) lead to decreased MTP transcription, less export of triglyceride from hepatocytes, and greater intracellular triglyceride accumulation. Therefore, functional polymorphisms in MTP may be involved in determining susceptibility to nonalcoholic steatohepatitis (NASH). The aim of this study is to examine the effect of some genetic influences among a group of obese Egyptian children.