Open AccessMucin-secreting gastric adenocarcinoma with Rhabdoid areas
Author(s) -
Sonal Sharma,
Richa Gupta,
Rajeev Sharma,
Mrinalini Kotru
Publication year - 2010
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.58769
Subject(s) - pathology , immunohistochemistry , vimentin , medicine , eosinophilic , adenocarcinoma , nucleolus , gastrointestinal tract , mucin , cancer , nucleus , psychiatry
Rhabdoid tumor, first described in kidneys of infants and children, is an aggressive tumor that has been reported in several extrarenal locations. In this report, we describe the case of a 40-year-old patient with gastric adenocarcinoma composed of histologically well-differentiated glandular areas and focal rhabdoid zones. The rhabdoid component showed typical features such as abundant eosinophilic cytoplasm, eccentric nuclei, prominent nucleoli and intense focal positive immunohistochemical cytoplasmic reaction for vimentin. Recognition of the rhabdoid phenotype in gastrointestinal tract neoplasms is important because this feature is associated with poor prognosis and unresponsiveness to conventional therapy.