Open AccessThe effects of amiloride and age on oxygen consumption coupled to electrogenic sodium transport in the human sigmoid colon
Author(s) -
Graciela E Carra,
D Matus,
Jorge E Ibáñez,
Fernando D. Saraví
Publication year - 2015
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.164190
Subject(s) - amiloride , oxygen , sodium , medicine , ussing chamber , endocrinology , chemistry , epithelium , pathology , organic chemistry
Aerobic metabolism is necessary for ion transport in many transporting epithelia, including the human colonic epithelium. We assessed the effects of the epithelial sodium channel blocker, amiloride, on oxygen consumption and short-circuit current of the human sigmoid epithelium to determine whether these effects were influenced by the age of the subject.