Open AccessNonalcoholic fatty liver disease progression in rats is accelerated by splenic regulation of liver PTEN/AKT
Author(s) -
Ziming Wang,
Naishu Li,
Biao Wang,
Jianhua Lin
Publication year - 2015
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.161641
Subject(s) - pten , tensin , nonalcoholic fatty liver disease , medicine , spleen , splenectomy , downregulation and upregulation , steatosis , endocrinology , protein kinase b , triglyceride , fatty liver , pi3k/akt/mtor pathway , biology , disease , cholesterol , phosphorylation , gene , apoptosis , biochemistry
The spleen has been reported to participate in the development of nonalcoholic fatty liver disease (NAFLD), but the mechanism has not been fully characterized. This study aims to elucidate how the spleen affects the development of NAFLD in a rat model.