Open AccessTopiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats
Author(s) -
Erkan Cüre,
Levent Tümkaya,
Yıldıray Kalkan,
İbrahim Aydın,
Aynur Kırbaş,
Arif Yılmaz,
Süleyman Yüce,
Mehmet Fatih Gökçe
Publication year - 2014
Publication title -
the saudi journal of gastroenterology/saudi journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 32
eISSN - 1998-4049
pISSN - 1319-3767
DOI - 10.4103/1319-3767.141690
Subject(s) - medicine , laparotomy , abdominal aorta , ischemia , reperfusion injury , liver injury , ligation , perfusion , gastroenterology , necrosis , abdominal surgery , anesthesia , aorta , surgery
Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-α) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury.