Open AccessCrescentic glomerulonephritis in non-asthmatic Churg-Strauss syndrome
Author(s) -
Anupma Kaul,
Raj Kumar Sharma,
K Jaisuresh,
Vinita Agrawal
Publication year - 2014
Publication title -
saudi journal of kidney diseases and transplantation/našrat amraḍ wa zira'aẗ al-kulaẗ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 30
eISSN - 2320-3838
pISSN - 1319-2442
DOI - 10.4103/1319-2442.128580
Subject(s) - medicine , eosinophilia , anti neutrophil cytoplasmic antibody , hypereosinophilia , prednisolone , glomerulonephritis , cyclophosphamide , vasculitis , renal biopsy , pathology , eosinophilic , biopsy , gastroenterology , chemotherapy , kidney , disease
A 58-year-old male presented with sensory motor polyneuropathy and rapidly progressive renal failure. Investigations revealed marked peripheral eosinophilia and elevated perinuclear antineutrophil cytoplasmic antibody titers. Renal biopsy showed pauci-immune cre-scentic glomerulonephritis with interstitial eosinophil infiltrates. He had no history of asthma. Computed tomography of the chest and X-ray of the paranasal sinuses were normal. On Day 1, the patient developed ileal perforation. Resected ileal segments showed small vessel vasculitis with extravascular eosinophils. A diagnosis of non-asthmatic variant of Churg-Strauss syndrome was made. Renal recovery was achieved in 12 weeks with a combination therapy of corticosteroid and cyclophosphamide. The patient has been relapse-free for 12 months on oral prednisolone therapy.