Open AccessThe effect of nitric oxide inhibitors and Snitroso-Nacetylpenicillamine on glucose concentration in an animal model
Author(s) -
Sophia Bryan,
Ruby Alexander-Lindo,
Tara P. Dasgupta,
Donovan McGrowder
Publication year - 2011
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.82314
Subject(s) - postprandial , medicine , nitric oxide , endocrinology , saline , chemistry , mole , arginine , pathophysiology , insulin , biochemistry , amino acid
Nitric oxide (NO) is becoming an increasingly important signaling molecule implicated in a growing number of physiological and pathophysiological processes. Research on the effect of NO donors on glucose metabolism in peripheral tissues have grown rapidly in the last decade. This study examined the effects of N(G)methyl-L-arginine acetate (L-NMMA) and N(G)methyl-L-arginine ester (L-NAME) on fasting and postprandial blood glucose concentrations. The study also investigated if L-NMMA and L-NAME decrease the hyperglycemic effect caused by the NO donor S-nitrosoN-acetylpenicillamine (SNAP) in normoglycemic rats.