Open AccessDoes a single loading dose of tranexamic acid reduce perioperative blood loss and transfusion requirements after total knee replacement surgery? A randomized, controlled trial
Author(s) -
Ratul Kundu,
Anjan Das,
Sandip Roy Basunia,
Tapas Bhattacharyya,
Surajit Chattopadhyay,
Anindya Mukherjee
Publication year - 2015
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.149099
Subject(s) - tranexamic acid , medicine , perioperative , anesthesia , saline , blood transfusion , surgery , hemoglobin , blood loss
Total knee replacement (TKR) is associated with high-perioperative blood loss, which often requires allogenic blood transfusion. Among the many strategies to decrease the need for allogenic transfusion, tranexamic acid (TA) is used systemically in perioperative setting with promising outcome. Here we evaluated the efficacy of single preoperative bolus dose of TA on reduction in blood loss and red blood cell transfusion in patients undergoing unilateral TKR.