Open AccessEvaluation of DNA damage in Type 2 diabetes mellitus patients with and without peripheral neuropathy: A study in South Indian population
Author(s) -
Mukul Prasad,
Stephen Charles Bronson,
Tushar Warrier,
Agnihotram Badarinath,
Shivam Rai,
Kaushal Baid,
Sneha Sitaraman,
Alex George,
Anand Moses,
Radha Saraswathy,
R. Vasuki,
Alagianambi Shanmugam
Publication year - 2015
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.149096
Subject(s) - diabetes mellitus , micronucleus test , medicine , peripheral neuropathy , population , micronucleus , diabetic neuropathy , type 2 diabetes , gastroenterology , incidence (geometry) , endocrinology , toxicity , physics , environmental health , optics
The increasing incidence of Type 2 diabetes mellitus globally has collaterally increased the incidence of diabetes-associated complications such as neuropathy. Oxidative stress induced DNA damage is one of the mechanisms implicated in the pathogenesis of diabetic complications. Here we aimed to evaluate the extent of DNA damage in diabetes patients with and without clinical neuropathy using the Cytokinesis Block Micronucleus Cytome assay, in a group of South Indian population.