Open AccessEvaluation of metformin hydrochloride in Wistar rats by FTIR-ATR spectroscopy: A convenient tool in the clinical study of diabetes
Author(s) -
P. Ramalingam,
Y. Padmanabha Reddy,
K. Vinod Kumar,
Babu Rao Chandu,
K. Rajendran
Publication year - 2014
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.136168
Subject(s) - metformin , metformin hydrochloride , diabetes mellitus , chemistry , biomolecule , hydrochloride , absorption (acoustics) , medicine , regimen , biomedical engineering , pharmacology , endocrinology , materials science , biochemistry , composite material
The IR absorption patterns (in cm(-1)) provide the basis to distinguish among the constituents and to separately quantify as well as qualify them and they possess many advantages such as very small sample volume requirement, good precision over entire physiological range, avoid of costly disposables, wealth of information from a single spectral measurement. The efficacy of anti-diabetic drug metformin hydrochloride as used to treat diabetic-induced Wistar rats and their sera were analyzed by FT-IR (ATR) in absorption mode.