Open AccessSearch of potential inhibitor against New Delhi metallo-beta-lactamase 1 from a series of antibacterial natural compounds
Author(s) -
Prasoon Kumar Thakur,
Jitender Kumar,
Divya Ray,
Farah Anjum,
Md. Imtaiyaz Hassan
Publication year - 2013
Publication title -
journal of natural science, biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.236
H-Index - 30
eISSN - 2229-7707
pISSN - 0976-9668
DOI - 10.4103/0976-9668.107260
Subject(s) - antibiotics , antibacterial activity , bacteria , chemistry , stereochemistry , new delhi , docking (animal) , antibiotic resistance , ic50 , hydrolysis , combinatorial chemistry , enzyme , microbiology and biotechnology , biology , biochemistry , in vitro , medicine , veterinary medicine , genetics , metropolitan area , pathology
New Delhi metallo-β-lactamase-1 (NDM-1)-producing Gram-negative bacteria are today's major worldwide health concern. The enzyme NDM-1 provides bacterial resistance by its hydrolytic activity against the β-lactam ring of antibiotics. Inhibition of NDM-1 may prevent the hydrolysis of β-lactam ring of the antibiotics, and therefore, plays an important role against antibacterial resistance.