Open AccessCalcitonin gene-related peptide and menopause
Author(s) -
Sudhaa Sharma,
Annil Mahajan,
Vishal R Tandon
Publication year - 2010
Publication title -
journal of mid-life health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.423
H-Index - 11
eISSN - 0976-7819
pISSN - 0976-7800
DOI - 10.4103/0976-7800.66985
Subject(s) - calcitonin gene related peptide , vasomotor , menopause , calcitonin , pathophysiology , medicine , endocrinology , depression (economics) , receptor , bioinformatics , neuropeptide , biology , economics , macroeconomics
The review summarizes recent findings with respect to pathophysiological role of calcitonin gene-related peptide (CGRP), in postmenopausal symptoms and diseases, which has opened horizons in understanding pathophysiology of menopause in a better way. Current evidences strongly propose a need to develop CGRP receptor antagonists, which may prove beneficial in many prevalent menopausal symptom/diseases such as vasomotor symptoms, cardiovascular risk, obesity, and major depressive disorder, in which CGRP levels are elevated.