Open AccessEffects of structural analogues of apelin-12 in acute myocardial infarction in rats
Author(s) -
О. И. Писаренко,
L. I. Serebryakova,
И. М. Студнева,
Yu. A. Pelogeykina,
O. V. Tskitishvili,
Zhanna D. Bespalova,
M. V. Sidorova,
А. А. Азьмуко,
Denis N. Khatri,
M. E. Palkeeva,
А. С. Молокоедов
Publication year - 2013
Publication title -
journal of pharmacology and pharmacotherapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.301
H-Index - 34
eISSN - 0976-5018
pISSN - 0976-500X
DOI - 10.4103/0976-500x.114600
Subject(s) - medicine , apelin , myocardial infarction , saline , cardiology , ischemia , reperfusion injury , antagonist , pharmacology , receptor
To examine cardioprotective effects of Ρ-terminal fragment of adipokine apelin-12 (A12), its novel structural analogue [MeArg(1), NLe(10)]-A12 (I), and [d-Ala(12)]-A12 (II), a putative antagonist of APJ receptor, employing in vivo model of ischemia/reperfusion (I/R) injury.