Open AccessDapsone hypersensitivity syndrome: A rare life threatening complication of dapsone therapy
Author(s) -
Kolar Vishwanath Vinod,
Arun Karyampudi,
Tarun Kumar Dutta
Publication year - 2013
Publication title -
journal of pharmacology and pharmacotherapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.301
H-Index - 34
eISSN - 0976-5018
pISSN - 0976-500X
DOI - 10.4103/0976-500x.110917
Subject(s) - dapsone , medicine , rash , complication , dermatology , eosinophilia , hypersensitivity reaction , adverse effect , hepatitis , surgery , immunology
Dapsone can cause several adverse effects, the most serious being dapsone hypersensitivity syndrome (DHS), which is potentially fatal. Here we report a case of severe, life threatening dapsone systemic hypersensitivity syndrome in a 17-year-old male who presented with high grade fever, eosinophilia, lymphadenopathy, skin rash, hepatitis and encephalopathy, which was managed successfully with oral steroids. The case is being reported to emphasize the need for timely diagnosis and prompt treatment of this rare complication for successful outcomes. DHS is also reviewed in brief.