Open AccessRole of oxidative stress in the pathogenesis of oral submucous fibrosis: A preliminary prospective study
Author(s) -
GK Shakunthala,
Rajeshwari G Annigeri,
Shantala Arunkumar
Publication year - 2015
Publication title -
contemporary clinical dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 21
eISSN - 0976-237X
pISSN - 0976-2361
DOI - 10.4103/0976-237x.166823
Subject(s) - oral submucous fibrosis , oxidative stress , malondialdehyde , thiobarbituric acid , medicine , etiology , pathogenesis , gastroenterology , antioxidant , reactive oxygen species , prospective cohort study , analysis of variance , oxidative phosphorylation , physiology , pathology , lipid peroxidation , biochemistry , biology
In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF.