Open AccessImmunohistochemical expression of vascular endothelial growth factor in keratocystic odontogenic tumor, dentigerous cyst, and radicular cyst: A comparative study
Author(s) -
Nidhi Khajuria,
Rashmi Metgud,
Smitha Naik,
Sahul Lerra,
Priya Tiwari,
. Mamta,
Payal Katakwar,
Anirudh Tak
Publication year - 2016
Publication title -
indian journal of dentistry
Language(s) - English
Resource type - Journals
ISSN - 0975-962X
DOI - 10.4103/0975-962x.179378
Subject(s) - dentigerous cyst , keratocystic odontogenic tumor , pathology , connective tissue , radicular cyst , vascular endothelial growth factor , immunohistochemistry , biology , stroma , ctgf , cyst , medicine , growth factor , odontogenic , cancer research , vegf receptors , receptor , biochemistry
Cyst and tumors arise from tissue remains of odontogenesis, these interactions have been considered to play an important role in the tumorigenesis of odontogenic lesions. The connective tissue stroma has an essential role in the preservation of epithelial tissues and minor alterations in the epithelium are followed by corresponding changes in the stroma, such as angiogenesis. Vascular endothelial growth factor (VEGF) is considered the first factor which maintains its position as the most critical driver of vascular formation and is required to initiate the formation of immature vessels, with this aim, present study was executed to evaluate VEGF expression in kertocystic odontogenic tumor, dentigerous cyst and radicular cyst (RC).