Open AccessDiuretic activity of Linaria ramosissima (wall.) Janch. leaves in albino rats
Author(s) -
Preeti Pandya,
Hetal Aghera,
B K Ashok,
Rabinarayan Acharya
Publication year - 2012
Publication title -
ayu
Language(s) - English
Resource type - Journals
eISSN - 0976-9382
pISSN - 0974-8520
DOI - 10.4103/0974-8520.110517
Subject(s) - diuretic , urine , excretion , scrophulariaceae , potassium , sodium , diuresis , chemistry , pharmacology , medicine , traditional medicine , botany , biology , endocrinology , kidney , organic chemistry
Linaria ramosissima (Wall.) Janch., Scrophulariaceae, a folklore plant, has been claimed for its diuretic activities by traditional practitioners. The present study was undertaken to investigate the diuretic activity of L. ramosissima leaves in albino rats. Suspension of leaf powder in 2% gum acacia was administered to experimental rats orally at doses of 450 mg/kg. The diuretic effect was evaluated by measuring the urine volume, pH of urine, and urinary electrolyte excretion. Administration of the test drug increased the urine volume in a non-significant manner, while it enhanced the urinary excretion of sodium, chloride, and potassium significantly, in comparison to the control group. From the present study it can be concluded that the leaves of L. ramosissima have a significant diuretic activity.