Open AccessEvaluation of subchronic genotoxic potential of Swarna Makshika Bhasma
Author(s) -
Pavan B Savalgi,
Biswajyoti Patgiri,
Jalaram H Thakkar,
B Ravishankar,
Varun Gupta
Publication year - 2012
Publication title -
ayu
Language(s) - English
Resource type - Journals
eISSN - 0976-9382
pISSN - 0974-8520
DOI - 10.4103/0974-8520.108858
Subject(s) - genotoxicity , cyclophosphamide , traditional medicine , toxicology , pharmacology , medicine , biology , toxicity , chemotherapy
Extremely diminutive published information is available on the mutagenic activity of Ayurvedic Bhasmas. Genotoxicity of few Bhasmas were reported on single maximum dose, but no reference is available on the sub-chronic level. Hence the present study was carried to generate and evaluate genotoxic potentials of Swarna Makshika Bhasma (mineral preparation) administered at therapeutic dose for 14 days. Chromosomal aberrations and abnormal sperm assay parameters were taken in this study. Cyclophosphamide (CP) was taken as positive group and results were compared. The results revealed a lack of generation of structural deformity in above parameters by tested drugs compared to CP treated group. Observed data indicate that the Bhasmas tested were non-genotoxic under the experimental conditions.