
Anti-ulcer activity of Lucer against experimentally induced gastric ulcers in rats
Author(s) -
Jigna Shah,
Jetun R Patel
Publication year - 2012
Publication title -
ayu
Language(s) - English
Resource type - Journals
eISSN - 0976-9382
pISSN - 0974-8520
DOI - 10.4103/0974-8520.105260
Subject(s) - ulcer index , aspirin , gastric acid , drug , gastric secretion , medicine , gastroenterology , secretion , pharmacology , mechanism of action , gastric mucosa , stomach , chemistry , in vitro , biochemistry
The present study is designed to explore the mechanism of action of herbal formulation Lucer against experimentally induced gastric ulcers. The aqueous extract (120 and 180 mg/kg) of Lucer was tested against aspirin and ethanol-induced gastric ulcer model in rats. The drug has been found to be very effective in inhibiting gastric ulceration. This is evident from reduction in ulcer index parameters. Besides, significant reduction in acid secretory parameters such as total acidity, total acid output and volume of gastric secretion were also observed. It is concluded from this study that the drug possesses anti-ulcer activity in both the models. The anti-ulcer activity of the drug can be attributed to inhibition of acid secretary parameters and strengthening of gastric mucosal barrier.