Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats

The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations.