Open AccessSub-acute effect of NG-nitro-l-arginine methyl-ester (L-NAME) on biochemical indices ins rats: Protective effects of Kolaviron and extract of Curcuma longa L
Author(s) -
Oluwatosin A. Adaramoye,
Ifeanyichukwu O. Nwosu,
Ebenezer O. Farombi
Publication year - 2012
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.99071
Subject(s) - chemistry , glutathione , antioxidant , superoxide dismutase , lipid peroxidation , nitric oxide , nitric oxide synthase , pharmacology , oxidative stress , glutathione peroxidase , malondialdehyde , biochemistry , medicine , enzyme , organic chemistry
Kolaviron (KV) (biflavonoid from Garcinia kola) and extract of Curcuma longa (CL) are frequently used in folk medicine for treatment of hypertension. One of their mechanisms of action is to enhance antioxidant properties in animals. N(G)- nitro- l- arginine methyl- ester (L- NAME) is L- arginine analogue, which by binding to Nitric Oxide Synthase (NOS) may induce hypertension partly due to increase in tissues oxidative stress.