Open AccessAntianaphylactic and mast cell stabilization activity of Strychnos potatorum Linn. seed
Author(s) -
Umesh Jayantarao Patil,
Anil Sidram Savali,
Manjunath C Jirankali
Publication year - 2011
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.85011
Subject(s) - mast cell , compound 48/80 , nitric oxide , pharmacology , histamine , chemistry , anaphylaxis , intraperitoneal injection , medicine , degranulation , allergy , immunology , biochemistry , receptor , organic chemistry
The antianaphylactic activity of Strychnos potatorum Linn seed extract was evaluated by using compound 48/80 induced anaphylaxis and mast cell stabilization was studied by using peritoneal mast cells of rats. The possible antianaphylactic and mast cell stabilization mechanism was evaluated by using compound 48/80 induced mast cell activation and level of nitric oxide in rat peritoneal mast cells.