Open AccessInhibitory effect of rutin and curcumin on experimentally-induced calcium oxalate urolithiasis in rats
Author(s) -
J V Ghodasara,
Anil T. Pawar,
Chinmay D. Deshmukh,
Bhanudas S. Kuchekar
Publication year - 2010
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.75462
Subject(s) - rutin , chemistry , curcumin , calcium , ethylene glycol , oxalate , crystalluria , calcium oxalate , pharmacology , kidney , excretion , urine , antioxidant , biochemistry , medicine , organic chemistry
Renal epithelial cell injury by reactive oxygen species is pre-requisite step in the pathogenesis of urolithiasis. Rutin and curcumin are polyphenolic compounds known to have antioxidant and anti-inflammatory activities, but their effect on urolithiasis is yet to be elucidated. In the present study, we have investigated the inhibitory effect of rutin and curcumin on calcium oxalate urolithiasis in Wistar albino rats.