Open AccessThe potent inhibitors of protein tyrosine phosphatase 1B from the fruits of Melaleuca leucadendron
Author(s) -
Azis Saifudin,
Subehan Lallo,
Yasuhiro Tezuka
Publication year - 2016
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.178644
Subject(s) - myrtaceae , protein tyrosine phosphatase , chemistry , botany , biology , traditional medicine , biochemistry , enzyme , medicine
Melaleuca leucadendron (Myrtaceae) is a kind of fruit used as Indonesian medicinal component and recorded in Jamu (tonic made of medical herbs) prescription records for the diabetes treatment. Its methanol extract exhibited a strong inhibitory activity with the half maximal inhibitory concentration (IC50) value of 2.05 μg/mL, while it is the same value with positive control RK-682.