Open AccessLactoferrin from Camelus dromedarius inhibits nuclear transcription Factor-kappa B activation, cyclooxygenase-2 expression and prostaglandin E2 production in stimulated human chondrocytes
Author(s) -
Naila Rasheed,
Abdullah Alghasham,
Zafar Rasheed
Publication year - 2016
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.175612
Subject(s) - prostaglandin e2 , transcription factor , cyclooxygenase , kappa , chemistry , microbiology and biotechnology , lactoferrin , prostaglandin , biology , enzyme , biochemistry , medicine , gene , linguistics , philosophy
Osteoarthritis (OA) is a progressive joint disorder, which remains the leading cause of chronic disability in aged people. Nuclear factor-kappa B (NF)-κB is a major cellular event in OA and its activation by interleukin-1β (IL-1β) plays a critical role in cartilage breakdown in these patients.