Open AccessAnalgesic and anti-Inflammatory effect of UP3005, a botanical composition Containing two standardized extracts of Uncaria gambir and Morus alba
Author(s) -
Mesfin Yimam,
Young-Chul Lee,
Tae Woo Kim,
Breanna Moore,
Peng Jiao,
Mei Hong,
HyunJin Kim,
Jeong-Bum Nam,
Miran Kim,
Jin-Sun Oh,
Sabrina Cleveland,
Eu-Jin Hyun,
Min Chen,
Qi Jia
Publication year - 2015
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.157995
Subject(s) - analgesic , ibuprofen , medicine , pharmacology , anti inflammatory , piroxicam , osteoarthritis , edema , cyclooxygenase , in vivo , arthritis , phytotherapy , tramadol , traditional medicine , chemistry , enzyme , pathology , biology , biochemistry , alternative medicine , microbiology and biotechnology
Osteoarthritis (OA) is a chronic debilitating degenerative joint disease characterized by cartilage degradation and synovial inflammation exhibited by clinical symptoms such as joint swelling, synovitis, and inflammatory pain. Present day pain relief therapeutics heavily relies on the use of prescription and over the counter nonsteroidal anti-inflammatory drugs as the first line of defense where their long-term usage causes detrimental gastrointestinal and cardiovascular-related side-effects. As a result, the need for evidence based safer and efficacious alternatives from natural sources to overcome the most prominent and disabling symptoms of arthritis is a necessity.