Open AccessChemical Constituents from the Leaves of Euphorbia ammak Growing in Saudi Arabia
Author(s) -
Essam AbdelSattar,
Dina R. Abou-Hussein,
Frank Petereit
Publication year - 2015
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.147136
Subject(s) - stigmasterol , hela , chloroform , chemistry , cytotoxicity , euphorbia , traditional medicine , chemical constituents , euphorbiaceae , in vitro , stereochemistry , biology , organic chemistry , botany , chromatography , biochemistry , medicine
Investigation of the chloroform extract of Euphorbia ammak leaves led to the isolation of three compounds: euphol (1), α-glutinol (2) and stigmasterol (3) Their structures were elucidated by 1D and 2D NMR, as well as by comparison with the reported data. Compounds 1-3 exhibited cytotoxicity in vitro against human cervical adenocarcinoma (Hela), among which, compound 1 showed the best activity.