Open AccessAmelioration of insulin resistance by Rk1+ Rg5complex under endoplasmic reticulum stress conditions
Author(s) -
Shree Priya Ponnuraj,
Fayeza Md Siraj,
Sera Kang,
Hae Yong Noh,
Jin-Woo Min,
Yeon-Ju Kim,
DeokChun Yang
Publication year - 2014
Publication title -
pharmacognosy research
Language(s) - English
Resource type - Journals
eISSN - 0976-4836
pISSN - 0974-8490
DOI - 10.4103/0974-8490.138257
Subject(s) - endoplasmic reticulum , tunicamycin , insulin resistance , ginseng , unfolded protein response , ginsenoside , chemistry , insulin , pharmacology , biology , endocrinology , medicine , biochemistry , pathology , alternative medicine
Diabetes mellitus is a metabolic syndrome exaggerated by stress conditions. Endoplasmic reticulum stress (ERS) impairs the insulin signaling pathway making the diabetic conditions worsen. Pharmacological agents are supplied externally to overcome this malfunction. Ginsenosides from Panax ginseng C.A Meyer possesses many pharmacological properties and are used for the treatment of diabetes.