Open AccessSignificance of p53 and ki-67 expression in prostate cancer
Author(s) -
Renuka Verma,
Veena Gupta,
Jaspreet Singh,
Monica Verma,
Gopal N. Gupta,
Sumiti Gupta,
Rajeev Sen,
Megha Ralli
Publication year - 2015
Publication title -
urology annals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.355
H-Index - 20
eISSN - 0974-7834
pISSN - 0974-7796
DOI - 10.4103/0974-7796.158507
Subject(s) - medicine , prostate cancer , grading (engineering) , immunohistochemistry , prostate , ki 67 , carcinoma , cancer , hyperplasia , oncology , pca3 , pathology , biology , ecology
Prostate cancer is a major health problem throughout the developed world. Tumor grade is one of the most important prognostic factors of prostate cancer. At present, adequate prognostic markers for prostate cancer progression are still lacking, in spite of intensive investigation. Accordingly, we studied the role of immunohistochemical (IHC) expression of p53 and Ki-67 as a prognostic factor in carcinoma prostate and correlated their expression with Gleason's grade.