Open AccessT-cell epitopes identified by BALB/c mice immunized with vaccinia expressing HIV-1 gag lie within immunodominant regions recognized by HIV-infected Indian patients
Author(s) -
Ashwini Shete,
Madhuri Thakar,
Srikanth Tripathy,
Chandrashekhar G. Raut,
Sekhar Chakrabarti,
Ramesh Paranjape
Publication year - 2011
Publication title -
journal of global infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 25
eISSN - 0974-8245
pISSN - 0974-777X
DOI - 10.4103/0974-777x.83530
Subject(s) - epitope , virology , elispot , vaccinia , immune system , hiv vaccine , group specific antigen , biology , antibody , antigen , immunology , immunization , virus , hiv antigens , modified vaccinia ankara , t cell , vaccination , gene , recombinant dna , vaccine trial , viral disease , genetics
Human immunodeficiency virus (HIV) antigens from transmitted strains of HIV would prove crucial in vaccine designing for prevention of HIV infection. Immune response generated by Vaccinia construct expressing the HIV-1 gag gene from transmitted Indian HIV-1 subtype C strain (Vgag) in BALB/c mice is reported in the present study along with the identification of epitopes responsible for induction of the immune response.