Open AccessCarba NP as a simpler, rapid, cost-effective, and a more sensitive alternative to other phenotypic tests for detection of carbapenem resistance in routine diagnostic laboratories
Author(s) -
Shivani Shinde,
Rajarshi Gupta,
Shweta S Raut,
Gita Nataraj,
Preeti Mehta
Publication year - 2017
Publication title -
journal of laboratory physicians
Language(s) - English
Resource type - Journals
eISSN - 0974-7826
pISSN - 0974-2727
DOI - 10.4103/0974-2727.199628
Subject(s) - ertapenem , clinical microbiology , carbapenem , enterobacteriaceae , microbiology and biotechnology , klebsiella pneumoniae , medicine , biology , meropenem , antibiotic resistance , antibiotics , escherichia coli , biochemistry , gene
Resistance to carbapenems due to carbapenemases has been increasingly noticed in Enterobacteriaceae . Clinical and Laboratory Standards Institute (CLSI) has recommended the latest Carba NP (CNP) test as a confirmatory test for carbapenemase production in Enterobacteriaceae . Low sensitivity of disk diffusion (DD) and modified Hodge test (MHT) may result in missing out of resistant strains which can adversely affect clinical management. The present study compares three phenotypic tests - CNP test, DD, and MHT for detection of carbapenemase production.