Open AccessEpidemiology of Rifampicin Resistant Tuberculosis and Common Mutations in rpoB Gene of Mycobacterium tuberculosis: A Retrospective Study from Six Districts of Punjab (India) Using Xpert MTB/RIF Assay
Author(s) -
Ramandeep Kaur,
Neerja Jindal,
Shilpa Arora,
Shajla Kataria
Publication year - 2016
Publication title -
journal of laboratory physicians
Language(s) - English
Resource type - Journals
eISSN - 0974-7826
pISSN - 0974-2727
DOI - 10.4103/0974-2727.180789
Subject(s) - rpob , rifampicin , mycobacterium tuberculosis , genexpert mtb/rif , tuberculosis , medicine , gene mutation , epidemiology , microbiology and biotechnology , virology , mutation , biology , gene , pathology , genetics
Xpert MTB/RIF assay has revolutionized the diagnosis of tuberculosis (TB) by simultaneously detecting the bacteria and resistance to rifampicin (RIF), a surrogate marker for multidrug-resistant TB (MDR-TB) in <2 h. The RIF resistance pattern in Malwa region of Punjab, India, is not documented. Here, we report the epidemiology of RIF-resistant TB and mutations in rpoB gene of Mycobacterium tuberculosis (MTB).