Open AccessTreatment of laser resistant granuloma faciale with intralesional triamcinolone acetonide and 5-fluorouracil combination therapy
Author(s) -
Diana L Norris,
Martine Apikian,
Greg Goodman
Publication year - 2015
Publication title -
journal of cutaneous and aesthetic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.44
H-Index - 13
eISSN - 0974-5157
pISSN - 0974-2077
DOI - 10.4103/0974-2077.158450
Subject(s) - medicine , triamcinolone acetonide , surgery , fluorouracil , biopsy , granuloma , dermatology , chemotherapy , pathology
This report describes a sixty year old male with biopsy proven Granuloma Faciale (GF). The patient had been unsuccessfully treated with multiple therapies. A mixture 0.8 ml 5-Fluorouracil (5FU) and 0.2 ml Kenacort-A was trialled initially to treat this patient, followed by a more varied mixture ratio. These were given at intervals ranging from two weeks to two months. The patient received a total of twenty injections over a period of more than three years. An excellent response was noted and the patient is now able to tolerate long treatment free periods of between nine and twelve months. 5FU is a simple injection material and can be considered by clinicians as an option for treatment of GF.