Open AccessMTHFR C677T polymorphism is associated with hyperlipidemia in women with polycystic ovary syndrome
Author(s) -
Madhu Jain,
Priyanka Pandey,
Narendra Kumar Tiwary,
Shuchi Jain
Publication year - 2012
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.97802
Subject(s) - methylenetetrahydrofolate reductase , odds ratio , polycystic ovary , medicine , genotype , hyperhomocysteinemia , gastroenterology , hyperlipidemia , homocysteine , confidence interval , endocrinology , biology , insulin resistance , genetics , diabetes mellitus , obesity , gene
Women with polycystic ovary syndrome (PCOS) are prone for coronary artery disease (CAD), and hyperhomocysteinemia is an independent risk factor for CAD. MTHFR deficiency is the most common cause of hyperhomocysteinemia, thereby provoking a possible association between PCOS and MTHFR C677T polymorphism.