Open AccessMicrodeletion of Y chromosome as a cause of recurrent pregnancy loss
Author(s) -
Sonal Agarwal,
Arjit Agarwal,
Anuradha Khanna,
Kiran Singh
Publication year - 2015
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.165145
Subject(s) - y chromosome microdeletion , miscarriage , azoospermia factor , recurrent miscarriage , etiology , gynecology , y chromosome , pregnancy , azoospermia , medicine , genetics , infertility , biology , obstetrics , gene
In majority of couples experiencing recurrent pregnancy loss (RPL), etiology is still unknown. Two genetic factors have been suggested to underlie miscarriage in a subset of patients, namely skewed X chromosome inactivation in females and Y chromosome microdeletions in their partners. In males, microdeletions of the Y chromosome are known to cause spermatogenetic failure and male infertility.