Open AccessOvert leptin response to controlled ovarian hyperstimulation negatively correlates with pregnancy outcome in in vitro fertilization--embryo transfer cycle
Author(s) -
Jana Chakrabarti,
Ratna Chatterjee,
S.K. Goswami,
Baidyanath Chakravarty,
Syed N. Kabir
Publication year - 2012
Publication title -
journal of human reproductive sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.484
H-Index - 31
eISSN - 0974-1208
pISSN - 1998-4766
DOI - 10.4103/0974-1208.101021
Subject(s) - leptin , endocrinology , controlled ovarian hyperstimulation , medicine , in vitro fertilisation , follicular fluid , ovarian hyperstimulation syndrome , embryo transfer , follicular phase , ovary , biology , andrology , pregnancy , embryo , obesity , oocyte , genetics , microbiology and biotechnology
A critical body mass of adipose tissue is essential for the normal development of female reproductive functions. Leptin, an adipocyte-derived hormone encoded by the 'Ob' gene has been proposed as a peripheral signal indicating the adequacy of nutritional status for reproductive functions. It is reported as a direct regulator of gametogenic and steroidogenic potential of ovary. Though leptin is widely present in reproductive tissues, its relationship to reproductive hormones is still poorly understood.