Open AccessDefining an appropriate leucoreduction strategy by serial assessment of cytokine levels in platelet concentrates prepared by different methods
Author(s) -
Daljit Kaur,
Ratti Ram Sharma,
Neelam Marwaha
Publication year - 2015
Publication title -
asian journal of transfusion science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 22
eISSN - 1998-3565
pISSN - 0973-6247
DOI - 10.4103/0973-6247.150945
Subject(s) - apheresis , medicine , platelet , buffy coat , platelet concentrate , cytokine , immunology , tumor necrosis factor alpha , plateletpheresis , platelet rich plasma , andrology , whole blood
Different methods of platelet concentrate preparations leave behind certain number of residual leukocytes, accounting for most of the febrile nonhemolytic transfusion reactions, especially in multitransfused patients. Various inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 are generated during storage and have been implicated for these adverse effects. We have studied the levels of these cytokines and their correlation with leucocyte contents in platelet concentrates prepared by three different methods.