Open AccessX-linked inhibitor of apoptosis protein inhibitor Embelin induces apoptosis via PI3K/Akt pathway and inhibits invasion in osteosarcoma cells
Author(s) -
Qian Hao,
Tao Huang,
Yao Chen,
Xiucheng Li,
Weihua Gong,
Guangjian Jiang,
Wei Zhang,
Shuo Cheng,
Xuhui Li,
Pengcheng Li
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.203599
Subject(s) - xiap , inhibitor of apoptosis , protein kinase b , apoptosis , osteosarcoma , pi3k/akt/mtor pathway , cancer research , chemistry , programmed cell death , inhibitor of apoptosis domain , caspase , biology , biochemistry
Embelin is an active compound identified as a novel X-linked inhibitor of apoptosis protein (XIAP) inhibitor from the Embelia ribes that exhibits various medicinal effects including anti-inflammatory and anticancer activities. However, the therapeutic effect of Embelin to human osteosarcoma is not yet determined.