Open AccessSymptomatic treatment of brain metastases in renal cell carcinoma with sorafenib
Author(s) -
Dongyan Hu,
Huixin Yu,
Jisheng Li,
Xiuwen Wang
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.189402
Subject(s) - sorafenib , medicine , renal cell carcinoma , brain metastasis , metastasis , nephrectomy , oncology , carcinoma , kidney , hepatocellular carcinoma , cancer
Brain metastasis is synchronous to the diagnosis of renal cell carcinoma (RCC). The prognosis of brain metastasis in RCC with the current treatment options is dismissal. Therefore, we present a case of an elderly female patient with RCC showing a partial response of brain metastasis after 18 months of 600 mg once daily sorafenib treatment who underwent right-sided nephrectomy. Further, withdrawal of sorafenib resulted in psychiatric changes along with increased metastasis lesions, which were recovered upon resuming the treatment, proposing that oral sorafenib can be used safely and efficiently for treatment of brain metastasis in advanced RCC.