Open AccessIdentifying key genes in retinoblastoma by comparing classifications of several kinds of significant genes
Author(s) -
Li Han,
Mei-Hong Cheng,
Min Zhang,
Kai Cheng
Publication year - 2018
Publication title -
journal of cancer research and therapeutics/journal of cancer research and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 39
eISSN - 0973-1482
pISSN - 1998-4138
DOI - 10.4103/0973-1482.180678
Subject(s) - gene , key (lock) , retinoblastoma , biology , computational biology , genetics , ecology
The objective of this paper was to investigate key genes in retinoblastoma using a novel method which is mainly based on five kinds of genes, differentially expressed genes (DEGs), differential pathway genes (DPGs), seed genes (common genes between DEGs and DPGs), hub genes and informative genes (common genes of hub genes and DEGs), and support vector machines (SVM) model.