Open AccessHispidulin-7-O-neohesperidoside from Cirsium japonicum var. ussuriense attenuates the production of inflammatory mediators in LPS-induced raw 264.7 cells and HT-29 cells
Author(s) -
Jong Chul Park,
Hyunji Yoo,
Cho Een Kim,
Sun-Yup Shim,
Mina Lee
Publication year - 2017
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.218116
Subject(s) - proinflammatory cytokine , nitric oxide , lipopolysaccharide , tumor necrosis factor alpha , nitric oxide synthase , anti inflammatory , pharmacology , chemistry , cytokine , inflammation , biochemistry , immunology , biology , organic chemistry
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and involves secretion of inflammatory mediators. The flavone diglycoside hispidulin-7- O -neohesperidoside (HN) isolated from the methanolic extract of aerial parts of Cirsium japonicum var. ussuriense , but its pharmacologic activities, with the exception of alleviation of alcohol toxicity, have not been investigated to date.