Open AccessEffect of procyanidin-rich extract from natural cocoa powder on cellular viability, cell cycle progression, and chemoresistance in human epithelial ovarian carcinoma cell lines
Author(s) -
Shruti Taparia,
Aparna Khanna
Publication year - 2016
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.182164
Subject(s) - viability assay , chemistry , cell cycle , polyphenol , flow cytometry , cell culture , proanthocyanidin , cell cycle checkpoint , cytotoxic t cell , cell growth , cell , pharmacology , cytotoxicity , mtt assay , antioxidant , cancer cell , in vitro , traditional medicine , cancer , biochemistry , biology , microbiology and biotechnology , medicine , genetics
Over the last 400 years, cocoa and chocolate have been described as having potential medicinal value, being consumed as a beverage or eaten as food. Concentration-dependant, antiproliferation, and cytotoxic effects of some of their polyphenolic constituents have been demonstrated against various cancers. Such an effect remains to be demonstrated in ovarian cancer.