Open AccessPreparation and evaluation of andrographolide solid dispersion vectored by silicon dioxide
Author(s) -
Dingkun Zhang,
Junzhi Lin,
Fang Zhang,
Xue Han,
Li Han,
Ming Yang,
Zou Wen-quan
Publication year - 2016
Publication title -
pharmacognosy magazine
Language(s) - English
Resource type - Journals
eISSN - 0976-4062
pISSN - 0973-1296
DOI - 10.4103/0973-1296.182156
Subject(s) - dissolution , dispersion (optics) , solvent , dissolution testing , silicon dioxide , materials science , analytical chemistry (journal) , chemical engineering , chemistry , chromatography , organic chemistry , physics , biopharmaceutics classification system , optics , metallurgy , engineering
Andrographolide (Andro) is a "natural antibiotic" as well as a typical insoluble drug. The purpose of this study was to investigate the feasibility of commercially available silica (SiO2) as a carrier of solid dispersion to enhance the dissolution of Andro.